Trillium Health Centre's two-site model facilitates the delivery of comprehensive services for both inpatient and ambulatory care with its Mississauga and West Toronto locations only five kilometres apart from each other. Both locations are supported by a full complement of diagnostic, laboratory and pharmaceutical services. A variety of community-based programs extend the hospital's outreach.
 
Trillium's services are provided under the umbrella of eight health systems which include:

Cardiac Services
Diagnostics & Pharmaceuticals
Emergency Services
Medicine
Mental Health
Neurosciences/Musculoskeletal Services
Surgery
Women's & Children's Health